Publications
2025
Cuttler C, Stueber A, Simone J, Mayo LM. Down the Rabbit Hole: A Large-Scale Survey of Psychedelic Users' Patterns of Use and Perceived Effects. Journal of Psychoactive Drugs https://doi.org/10.1080/02791072.2025.2452226
Jones MR, Haggarty CJ, Petrie GN, Lunge AR, Morrison I, Hill MN, Heilig M, Mayo LM. Endocannabinoid contributions to the perception of socially relevant, affective touch in humans. Neuropsychopharmacology https://doi.org/10.1038/s41386-025-02053-y
2024
Mazurka R, Harkness K, Hassel S, Stensson N, Nogovitsyn N, Poppenk J, Foster J, Squires S, Rowe J, Milev R, Wynne-Edwards K, Turecki G, Strother S, Arnott S, Lam R, Rotzinger S, Kennedy S, Frey B, Mayo LM. (in press). Endocannabinoid concentrations in major depression: Effects of childhood trauma and relation to hippocampal volume. Translational Psychiatry
Meshkat S, Tello-Gerez TJ, Gholaminezhad F, Dunkley BT, Reichelt AC, Erritzoe D, Veremetten E, Zhang Y, Greenshaw A, Burback L, Winkler O, Jetly R, Mayo LM, Bhat V (2024). Impact of psilocybin on cognitive function: A systematic review. Psychiatry Clin Neurosci http://doi.org/10.1111/pcn.13741
Lam GN, Cooper J, Lipp OV, Mayo LM, Ney L (2024). Exploration of stress reactivity and fear conditioning on intrusive memory frequency in a conditioned-intrusion paradigm. Journal of Behavior Therapy and Experimental Psychiatry https://doi.org/10.1016/j.jbtep.2024.101984
Kroll SL, Meier P, Mayo LM, Gertsch J, Quednow BB (2024). Endocannabinoids and related lipids linked to social exclusion in individuals with chronic non-medical prescription opioid use. Neuropsychopharmacology https://doi.org/10.1038/s41386-024-01881-8
Gowatch LC, Evanski JM, Ely SL, Zundel CG, Bhogal A, Carpenter C, Shampine MM, O’Mara E, Mazurka R, Barcelona J, Mayo LM, Marusak HA (2024). Endocannabinoids and stress-related neuropsychiatric disorders: A systematic review and meta-analysis of basal concentrations and response to acute psychosocial stress. Cannabis and Cannabinoid Research epub ahead of print: 29 April 2024. https://doi.org/10.1089/can.2023.0246
Yin J, Wany Y, Mayo LM, Ney LJ (2024). Examining the reliability of the emotional conflict resolution and adaptation effects in the emotional conflict task via secondary data analysis, systematic review, and meta-analysis. Journal of Experimental Psychology: General. 10.1037/xge0001552
2023
Kratina S, Mayo LM (2023). Tripping outside the lines: Lessons from observational studies of combination psychedelic use beyond regulated clinical contexts. The American Journal of Drug and Alcohol Abuse [Invited Commentary] http://doi.org/10.1080/00952990.2023.2246637
Perini I*, Mayo LM*, Capusan AJ, Paul ER, Yngve A, Kämpe R, Gauffin E, Mazurka R, Ghafouri B, Stensson N, Asratian A, Hamilton PJ, Kastbom A, Gustafsson PA, Heilig M (2023). Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation. Molecular Psychiatry https://doi.org/10.1038/s41380-023-02033-y
Ney LJ, Cooper J, Lam GN, Moffitt K, Nichols DS, Mayo LM, Lipp OV (2023). Hair endocannabinoids predict physiological fear conditioning and salivary endocannabinoids predict subjective stress reactivity in humans. Psychoneuroendocrinology 154:106296 http://doi.org/10.1016/j.psyneuen.2023.106296
Ney LJ, Akosile W, Davey C, Pitcher L, Felmingham KL, Mayo LM, Hill MN, Strodl E (2023). Challenges and considerations for treating PTSD with medicinal cannabis: the Australian clinician’s perspective. Expert Review of Clinical Pharmacology. http://doi.org/10.1080/17512433.2023.2276309.
2022
Mayo LM, Rabinak CA, Hill MN, Heilig M (2022). Targeting the endocannabinoid system in the treatment of PTSD: A promising case of preclinical-clinical translation? [Invited Review] Biological Psychiatry e- pub ahead of print 24 July 2021 https://doi.org/10.1016/j.biopsych.2021.07.01
Associated commentary: Schmidt M (2022). Modulating the endocannabinoid system as a therapeutic approach for posttraumatic stress disorder: could translational research on fear and extinction learning predict clinical benefit? Biological Psychiatry 91(3): 248-249 doi: https://doi.org/10.1016/j.biopsych.2021.10.014
Ney LJ, Crombie KM, Mayo LM, Felmingham KL, Bowser T, Matthews A (2022). Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next? Neuroscience and Biobehavioral Reviews 132:76-91 https://doi.org/10.1016/j.neubiorev.2021.11.040
Middleton SJ*, Perini I*, Themistocleous AC, Weir GA, McCann K, Barry AM, Marshall A, Lee M, Mayo LM, Bohic M, Baskozos G, Morrison I, Löken LS, McIntyre S, Naagi S, Staud R, Sehlstedt I, Johnson RD, Wessberg J, Wood, JN, Woods CG, Moqrich A, Olausson H, Bennett DL (2022). Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice Brain 2021 Dec 27:awab482. https://doi.org/10.1093/brain/awab482
2021
Capusan A, Gustafsson PA, Kuja-Halkola R, Igelström K, Mayo LM, Heilig M (2021). Re-examining the link between childhood maltreatment and substance use disorder: A prospective, genetically informative study. Molecular Psychiatry 6 April 2021 https://doi.org/10.1038/s41380-021-01071-8
Kroll SL, Mayo LM, Asratian A, Yngve A, Perini I, Heilig M (2021). Negative self-evaluation induced by acute stress indexed using facial electromyography. Psychoneuroendocrinology 133:105402 https://doi.org/10.1016/j.psyneuen.2021.105402
Perini I, Zetterqvist M, Mayo LM (2021). Beyond distress: A role for positive affect in nonsuicidal self-injury. Current Opinion in Behavioral Sciences Special Issue: Positive Affect 39:209-215 [Invited Contribution] https://doi.org/10.1016/j.cobeha.2021.04.012
Van Hedger K, Mayo LM, Bershad AK, Madray R, de Wit H (2021). Effects of acute drug administration on emotion: a review of pharmacological MRI studies Current Addiction Reports 14 March 2021 https://doi.org/10.1007/s40429-021-00362-y
Perini I, Gustafsson PA, Igelström K, Jokubaviciene B, Kämpe R, Mayo LM, Molander J, Olausson H, Zetterqvist M, Heilig M (2021). Altered relationship between subjective perception and central representation of touch hedonics in adolescents with autism spectrum disorder. Translational Psychiatry 11(1):224 https://doi.org/0.1038/s41398-021-01341-7
2020
Mayo LM, Asratian A, Linde J, Morena M, Haataja R, Hammar V, Augier G, Hill MN, Heilig M (2020). Elevated anandamide, enhanced recall of fear extinction, and attenuated stress responses following inhibition of fatty acid amide hydrolase (FAAH): a randomized, controlled experimental medicine trial. Biological Psychiatry 87(6):538-547 epub 2019 Aug 13 https://doi.org/10.1016/j.biopsych.2019.07.034
· Associated commentary: Piomelli, D (2020). Next stop for Fatty Acid Amide Hydrolase Inhibitors, the clinic? Biological Psychiatry 87(6): 485-486 https://doi.org/10.1016/j.biopsych.2019.11.020
Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli H, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M (2020). Protective effects of elevated anandamide on stress and fear-related behaviors: Translational evidence from humans and mice. Molecular Psychiatry 25(5):993-1005 epub 2018 Aug 17 https://doi.org/10.1038/s41380-018-0215-1
Mayo LM*, Perini I*, Gustafsson PA, Hamilton JP, Kämpe R, Heilig M, Zetterqvist M (2020). Psycho- physiological and neural support for enhanced emotional reactivity in adolescence females with nonsuicidal self-injury. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging epub ahead of print 24 Nov 2020 https://doi.org/10.1016/j.bpsc.2020.11.004
Zetterqvist M, Perini I, Mayo LM, Gustafsson PA (2020). Nonsuicidal self-injury disorder in adolescents: Clinical utility of the diagnosis using the Clinical Assessment of Nonsuicidal Self-Injury Disorder Index. Frontiers in Psychiatry 11:8 https://doi.org/10.3389/fpsyt.2020.00008
2019
Mayo LM, Heilig M (2019). In the face of stress: Interpreting individual differences in stress-induced facial expressions. Review. Neurobiology of Stress 10:100166 [Invited Contribution] https://doi.org/10.1016/j.ynstr.2019.100166
Mayo LM, Paul E, DeArcangelis J, Van Hedger K, de Wit H (2019). Gender differences in the behavioral and subjective effects of methamphetamine in healthy humans. Psychopharmacology Special Issue: Computational Translational Neuropsychopharmacology 236(8): 2413-2423. [Invited Contribution] https://doi.org/10.1007/s00213-019-05276-2
Ree A, Morrison I, Olausson H, Sailer U, Heilig M, Mayo LM (2019). Using facial electromyography to assess facial muscle reactions to experienced and observed touch in humans. Journal of Visualized Experiments 2019 Mar 15;(145) https://doi.org/10.3791/59228 [Invited Contribution]
Bershad AK, Mayo LM, Van Hedger K, McGlone F, Walker SC, de Wit H (2019). Effects of MDMA on attention to positive social cues and pleasantness of affective touch. Neuropsychopharmacology 44(10):1698-1705 https://doi.org/10.1038/s41386-019-0402-z
Ree A, Mayo LM, Leknes S, Sailer U (2019). Touch targeting C-tactile afferent fibers has a unique physiological pattern: a combined electrodermal and facial electromyography study. Biological Psychology 2018 Nov 20. pii: S0301-0511(18)30143-1 https://doi.org/10.1016/j.biopsycho.2018.11.006
Perini I, Gustafsson PA, Hamilton PJ, Kämpe R, Mayo LM, Heilig M, Zetterqvist M (2019). Brain-based classification of negative social bias in adolescents with nonsuicidal self-injury: Findings from simulated online social interaction EClinical Medicine 13:81-90 https://doi.org/10.1016/j.eclinm.2019.06.016
2018
Mayo LM, Lindé J, Olausson H, Heilig M, Morrison I (2018). Putting a good face on touch: Facial expression reflects the affective valence of caress-like touch across modalities. Biological Psychology 137: 83-90 https://doi.org/10.1016/j.biopsycho.2018.07.001
Mayo LM, Heilig M (2018). A hippocampal signature of posttraumatic stress disorder vulnerability. Biological Psychiatry 48(2): 78-79 https://doi.org/10.1016/j.biopsych.2018.04.015 [Invited Commentary]
Van Hedger K, Keedy S, Mayo LM, Heilig M, de Wit H (2018). Neural responses to cues paired with methamphetamine in healthy volunteers. Neuropsychopharmacology 43(8): 1732-1737 https://doi.org/ 10.1038/s41386-017-0005-5
2016
Spagnolo P, Ramchandani V, Schwandt M, Kwako L, George D, Mayo LM, Hillard CJ, Heilig M (2016). FAAH gene variation moderates stress response and symptom severity in patients with post-traumatic stress disorder and comorbid alcohol dependence. Alcohol Clin Exp Res 40(11): 2426-2432 https://doi.org/10.1111/acer.13210
Mayo LM, de Wit H (2016). Acquisition of conditioned responses to a novel alcohol-paired cue in non-dependent drinkers. J Stud Alcohol Drugs 77(2): 317-326 https://doi.org/10.15288/jsad.2016.77.317
Cavallo JS, Mayo LM, de Wit H (2016). Acquisition of conditioning between methamphetamine and cues in healthy humans. PLoS ONE 11(8), e0161541 https://doi.org/10.1371/journal.pone.0161541
2015
Mayo LM, de Wit H (2015). Acquisition of responses to a methamphetamine-associated cue in healthy humans: Self-report, behavioral, and psychophysiological measures. Neuropsychopharmacology 40(7): 1734-1741 https://doi.org/10.1038/npp.2015.21
2013
Mayo LM, Fraser D, Childs E, Momenan R, Hommer D, de Wit H, Heilig M (2013). Conditioned preference to a methamphetamine-associated contextual cue in humans. Neuropsychopharmacology 38(6): 921-929 https://doi.org/10.1038/npp.2013.3
2011
Wardle MC, Treadway MT, Mayo LM, Zald DH, de Wit H (2011). Amping up effort: Effects of d- Amphetamine on human effort-based decision-making. J Neurosci 31(46): 16597-165602 https://doi.org/10.1523/JNEUROSCI.4387-11.2011
García-Fuster MJ, Flagel SB, Mahmood T, Mayo LM, Thompson RC, Watson SJ, Akil H (2011). Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD. Neuropsychopharmacology 36(11): 2303-2317 https://doi.org/10.1038/npp.2011.119
Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PEM, Akil H (2011). A selective role for dopamine in stimulus-reward learning. Nature 469: 53-57 https://doi.org/10.1038/nature09588